Table 1 Proteins quantified by iTRAQ-MARS. Identification and quantification of proteins were performed using the Protein Pilot Paragon Method.

From: Human coelomic fluid investigation: A MS-based analytical approach to prenatal screening

 

Accessiona

Namea

Gene Namea

B115:P114b

A116:P114b

C117:P114b

1

RM10_HUMAN

39 S ribosomal protein L10, mitochondrial

MRPL10

1.08

1.03

0.66

2

APCL_HUMAN

Adenomatous polyposis coli protein 2

APC2

3.67

6.62

4.88

3

SIA7E_HUMAN

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

ST6GALNAC5

1.42

2.14

1.74

4

RNPL1_HUMAN

Arginyl aminopeptidase-like 1

RNPEPL1

0.21

0.68

0.75

5

ANPRB_HUMAN

Atrial natriuretic peptide receptor 2

NPR2

1.38

3.67

2.76

6

CTF8A_HUMAN

Chromosome transmission fidelity protein 8 homolog isoform 2

CHTF8

2.44

4.11

3.30

7

CC183_HUMAN

Coiled-coil domain-containing protein 183 (Isoform 4)

CCDC183

2.35

2.05

1.43

8

CC186_HUMAN

Coiled-coil domain-containing protein 186

CCDC186

1.55

3.86

1.94

9

CO5A1_HUMAN

Collagen alpha-1(V) chain

COL5A1

1.98

3.36

2.92

10

CR2_HUMAN

Complement receptor type 2 (Isoform D)

CR2

1.81

3.22

2.47

11

NEUL1_HUMAN

E3 ubiquitin-proteinligase NEURL1

NEURL1

1.49

3.96

2.57

12

FLNC_HUMAN

Filamin-C

FLNC

1.23

3.94

3.93

13

GRASP_HUMAN

General receptor for phosphoinositides 1-associated scaffold protein (isoforms 2)

GRASP

1.24

2.56

2.20

14

GLHA_HUMAN

Glycoprotein hormones alpha chain

CGA

1.52

1.71

1.72

15

GCC2_HUMAN

GRIP and coiled-coil domain-containing protein 2

GCC2

1.61

4.83

3.08

16

H3C_HUMAN

Histone H3.3C

H3F3C

2.06

4.63

3.39

17

HV311_HUMAN

Ig heavy chain V-III region KOL

IGHV3–33

1.37

2.52

0.81

18

IPO8_HUMAN

Importin-8

IPO8

1.36

1.60

1.73

19

G137C_HUMAN

Integral membrane protein GPR137C

GPR137C

2.00

4.20

2.60

20

ITIH1_HUMAN

Inter-alpha-trypsin inhibitor heavy chain H1

ITIH1

2.02

1.34

1.31

21

DCP2_HUMAN

m7GpppN-mRNA hydrolase

DCP2

1.10

3.52

2.50

22

MPEG1_HUMAN

Macrophage-expressed gene 1 protein

MPEG1

2.33

6.14

2.93

23

KISS1_HUMAN

Metastasis-suppressor KiSS-1

KISS1

3.38

2.63

1.64

24

MIIP_HUMAN

Migration and invasion-inhibitory protein

MIIP

2.36

4.22

3.47

25

MINT_HUMAN

Msx2-interacting protein

SPEN

1.73

3.85

4.55

26

MUC16_HUMAN

Mucin-16

MUC16

2.40

5.37

4.02

27

MUC19_HUMAN

Mucin-19

MUC19

1.87

4.26

2.44

28

MCTP1_HUMAN

Multiple C2 and transmembrane domain-containing protein 1

MCTP1

3.11

7.33

2.57

29

ACM1_HUMAN

Muscarinic acetylcholine receptor M1

CHRM1

1.00

2.49

1.43

30

NDUA5_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (Isoform2)

NDUFA5

1.09

2.85

3.08

31

PK3CG_HUMAN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PIK3CG

2.36

2.39

1.86

32

PMF1_HUMAN

Polyamine-modulated factor 1 (Isoform 2)

PMF1

1.40

0.00

0.86

33

PSME2_HUMAN

Proteasome activator complex subunit 2

PSME2

1.50

5.20

1.24

34

K1456_HUMAN

Putative methyltransferase KIAA1456

KIAA1456

1.57

2.94

1.97

35

SHSA8_HUMAN

Putative protein shisa-8

SHISA8

2.24

4.32

2.90

36

RANB9_HUMAN

Ran-binding protein 9 (Isoform 2)

RANBP9

2.28

2.35

2.82

37

RALB_HUMAN

Ras-related protein Ral-B

RALB

0.26

1.28

0.07

38

EWS_HUMAN

RNA-binding protein EWS

EWSR1

1.03

1.89

1.06

39

SPCS3_HUMAN

Signal peptidase complex subunit 3

SPCS3

1.33

3.49

2.63

40

SLF2_HUMAN

SMC5-SMC6 complex localization factor protein 2

SLF2

1.29

0.78

2.63

41

SPEG_HUMAN

Striated muscle preferentially expressed protein kinase

SPEG

1.30

3.85

1.41

42

TPC12_HUMAN

Traffickingproteinparticlecomplexsubunit 12

TRAPPC12

0.81

2.30

0.99

43

TRIM3_HUMAN

Tripartite motif-containing protein 3 (Isoform Gamma)

TRIM3

3.14

6.92

4.49

44

UBP37_HUMAN

Ubiquitin carboxyl-terminal hydrolase 37

USP37

1.54

2.48

1.58

45

CX023_HUMAN

Uncharacterized protein CXorf23

CXorf23

1.90

3.49

2.91

46

WDR97_HUMAN

WD repeat-containing protein KIAA1875

WDR97

2.78

2.42

3.45

47

XKR7_HUMAN

XK-related protein 7

XKR7

0.95

2.47

2.07

48

ZC11A_HUMAN

Zinc finger CCCH domain-containing protein 11A

ZC3H11A

2.17

4.67

2.06

49

ZN592_HUMAN

Zinc finger protein 592

ZNF592

2.96

6.72

6.03

  1. The MS/MS data were processed using a mass tolerance of 10 ppm and 0.2 Da for the precursor and fragment ions, respectively. aAccording to “UniProtKB” (http://www.uniprot.org/). bThe relative quantification was calculated according to Protein Pilot, and based on the ratio of the reporter ions corresponding to the A116, B115 and C117 tryptic peptides, over the ratio of the P114 reporter ions. Proteins giving tryptic peptides with an average reporter ion ratio ≥2 or ≤0.5 were classified as up- or down-regulated, respectively.
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