Figure 1
From: Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production
GPR3-DPI complex docking results. In all the panels the GPR3 receptor is shown in salmon and its agonist DPI is shown in cyan. Residues side chains located in the orthosteric binding cavity are shown in cyan, while residues located in the sodium allosteric binding cavity are shown in red. The receptor is oriented with the N-terminus in the extracellular part and the C-terminus in the intracellular part (A), DPI and side chains of residues 5 Å distant from the agonist are shown in cyan (B), chemical structure of DPI with the iodine atom indicated in violet (C), side chains of residues involved in allosteric sodium binding are shown in red (D).
