Figure 5 | Scientific Reports

Figure 5

From: Lung resident mesenchymal cells isolated from patients with the Bronchiolitis Obliterans Syndrome display a deregulated epigenetic profile

Figure 5

SAHA hinders TGF-β1-induced cell differentiation into myofibroblasts. (a) Quantitative RT-PCR results of pro-fibrotic genes (TGF-β1, FN1, aSMA) in MRC5 treated with or without SAHA and/or TGF-β1. Data are expressed as Mean (±SD). Three independent experiments were carried out with three replicatesfor each experimental condition. (b) Graphical representation of wound healing assay (magnification 10x). Data were obtained by two different observers. Results shown are the mean of three independent experiments ± SD (two replicates for each treatment). One star (*) indicates a p ≤ 0.05, while two stars (**) indicate a p ≤ 0.01, compared to control group; # and ## indicate a p ≤ 0.05, or p ≤ 0.01, respectively, compared to TGF-β1-treated group, two-tailed Student’s test.

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