Figure 4 | Scientific Reports

Figure 4

From: Analysis of naturally occurring mutations in the human uptake transporter NaCT important for bone and brain development and energy metabolism

Figure 4

Citrate uptake mediated by wild-type and mutated NaCT proteins. Uptake of citrate (1 µM) into transiently-transfected HEK293 cells. Parental HEK293 cells were transiently-transfected and citrate uptake was measured under established experimental conditions. Cells were transfected with expression plasmids containing cDNAs encoding the wild-type NaCT protein (wild-type) or different mutant NaCT proteins. Citrate net uptake mediated by the wild-type NaCT protein was set to 100% and all net uptake values are given in relation to this uptake ± SD. ***P < 0.001

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