Table 2 Loci disrupted in bile-sensitive mutants and the functions of gene products.

From: Metagenomics of pigmented and cholesterol gallstones: the putative role of bacteria

Genes disrupted in bile-sensitive mutants

Function of gene products/putative function

Reference(s)

Gram-negative bacteria

Klebsiella

   marA

Multiple antibiotic resistance protein – Regulatory genes

11,19,20

   marB

Multiple antibiotic resistance protein – Regulatory genes

11,19,20

   marC

Multiple antibiotic resistance protein – Regulatory genes

11,19,20

   marR

Regulatory genes

11,19,20

   TolC precursor

Efflux pump function

17,21

   dam

DNA adenine methylase

24

   emrE

Efflux pump –drug resistance

31

   emrB

Efflux pump – drug resistance

31

   mdtABCD

Efflux pump –multi drug resistance

22,31

   cmeA

Efflux pump

23,31

   cmeB

Efflux pump

23,31

   sbcC

Exonuclease

25

   MutS

DNA mismatch repair

25

   nifJ homolog

Pyruvate flavodoxin oxidoreductase

25

   yvaG

3-oxoacyl-acyl-carrier protein reductase

25

   dgt homolog

Deoxyguanosinetriphosphate triphosphohydrolase

25

Escherichia

   yvaG

3-oxoacyl-acyl-carrier protein reductase

25

Shigella

   PhoQ

Regulatory genes

34

Gram-positive bacteria

Enterococcus

   emrB

Efflux pump – drug resistance

31

   sbcC homolog

Exonuclease

25

   MutS

DNA mismatch repair

25

   nifJ homolog

Pyruvate-flavodoxin oxidoreductase

25

   yvaG

3-oxoacyl-acyl-carrier protein reductase

25

   dgt homolog

Deoxyguanosinetriphosphate triphosphohydrolase

25

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