Figure 3 | Scientific Reports

Figure 3

From: Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient

Figure 3

SCN5A and Nav1.5 expressions and INa measured in hiPSC-CMs. (A) Level of SCN5A mRNA in BrS1 (hiPSC-CMs from a BrS patient with compound SCN5A mutations) and CON1 (the sib of BrS1) determined by qPCR. n = 3. (B) Representative traces of sodium currents in the control (CON1) and patient (BrS1). (C) Peak INa density measured in BrS1 and CON1. (D–F) Steady state (SS)-inactivation, activation and recovery from inactivation curves of INa. Values given are mean ± SEM. †p < 0.01; vs. CON1.

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