Figure 5 | Scientific Reports

Figure 5

From: Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient

Figure 5

Effects of low heart rates on APs of BrS1 and CON1 hiPSC-CMs. (A, B1 and B2) (Top): representative superimposed AP waveforms recorded from CON1 and two BrS1 subgroups (non-early repolarization and early repolarization), sequentially paced at 1.0 Hz, 0.5 Hz and 0.1 Hz. (A, B1 and B2) (Bottom): superimposed AP waveforms continually recorded from CON1 and two BrS1 subgroups sequentially paced at 1.0 Hz and 0.1 Hz. (C) Main AP parameters plotted and compared among groups in bar-graphs. Values given are mean ± SEM. Statistics were performed with two-way repeated measures ANOVA followed by the Bonferroni post hoc testing. *p < 0.05; †p < 0.01; ‡P < 0.001. Black symbols: Intra-(sub) group comparisons. 0.1 Hz/0.5 Hz vs. 1.0 Hz. Pink symbols: vs. BrS1 (non-ER subgroup) at the same frequency. Green symbols: vs. CON1 subgroup at 1.0, 0.5 and 0.1 Hz.

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