Figure 6 | Scientific Reports

Figure 6

From: Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient

Figure 6

Validation of the rate-dependent effects on APs in BrS2 and CON2. (A) Representative superimposed AP waveforms of a CON2 cell paced at 1.0 and 0.1 Hz at 24 °C. (B and C) Representative superimposed AP waveforms of BrS2 cells paced at 1 and 0.1 Hz at 24 °C and 34 °C, respectively. (D) Main AP parameters are plotted and compared among groups in bar-graphs. Values given are mean ± SEM. Statistics were performed with two-way repeated measures ANOVA followed by the Bonferroni post hoc testing (by paired t-test). *p < 0.05; ‡P < 0.001.

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