Figure 7 | Scientific Reports

Figure 7

From: Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient

Figure 7

Effects of heart rates on Ito in hiPSC-CMs. (A-left and B-left) Representative traces of Ito currents recorded from CON1 (n = 26) and BrS (n = 22) paced at 1.0 Hz and 0.1 Hz. (A-middle and B-middle) I-V relationships of Ito show the current densities. (A-right and B-right) Graphic demonstrations and comparisons of Ito (recorded at +50 mV) in each cell are presented. Values given are mean ± SEM. §p < 0.0001; ||p < 0.00001; vs. 1.0 Hz (by paired t-test and one-way ANOVA test). ‡P < 0.001, vs. low Ito group.

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