Figure 8 | Scientific Reports

Figure 8

From: Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient

Figure 8

Effects of 4-AP and flecainide on APs. (A) Representative superimposed AP waveforms of a BrS1 cell paced at 0.1 Hz and subsequently exposed to 0.05 mM and 0.5 mM 4-AP. Main AP parameters (showing only the results of 0.5 mM 4-AP) are presented in bar-graphs. (B) Representative superimposed AP waveforms of a V-like BrS1 hiPSC-CM paced at 1.0 Hz followed by flecainide (10 µM) treatment. Main AP parameters are presented in bar-graphs. Values given are mean ± SEM. *p < 0.05; †p < 0.01; §p < 0.0001; ||p < 0.00001 (by paired t-test); vs. 0.1 Hz (for 4-AP) or 0.1 Hz (for flecainide).

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