Table 2 The 5 most upregulated and 5 most downregulated genes that were highly expressed in NP.

From: Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps

Gene

P value

Adjusted P value (FDR)

Log fold change

NP (FPKM)

IT (FPKM)

Upregulated

   POSTN

4.02 × 10−4

3.58 × 10−3

3.11

7.98 × 102

4.96 × 10

   ALOX15

3.92 × 10−3

2.21 × 10−2

3.07

6.34 × 102

8.02 × 10

   CST1

4.03 × 10−3

2.26 × 10−2

4.77

6.29 × 102

8.53

   SERPINB3

8.30 × 10−4

6.41 × 10−3

2.90

5.45 × 102

1.31 × 102

   CCL18

1.23 × 10−11

1.07 × 10−9

6.83

3.94 × 102

9.27 × 10−1

Downregulated

   BPIFA1

1.40 × 10−3

9.77 × 10−3

−3.01

4.13 × 103

2.66 × 104

   SLPI

9.77 × 10−7

2.63 × 10−5

−2.16

3.00 × 103

1.11 × 104

   BPIFB1

9.02 × 10−5

1.12 × 10−3

−2.74

2.02 × 103

1.18 × 104

   STATH

7.00 × 10−13

7.96 × 10−11

−10.8

9.14 × 102

6.71 × 104

   LTF

1.29 × 10−9

7.28 × 10−8

−4.47

8.27 × 102

6.92 × 103

  1. Log fold change indicates the logarithm base 2 log fold change of count per million (CPM) mapped reads; NP, nasal polyp; IT, inferior turbinate; NP (FPKM) and IT (FPKM) represent averages of fragments per kilobase of transcript per million mapped fragments (FPKM) in NP and IT samples, respectively; POSTN, periostin; ALOX15, arachidonate 15-lipoxygenase; CST1, cystatin SN; SERPINB3, serpin peptidase inhibitor, clade B (ovalbumin), member3; CCL18, C-C motif chemokine ligand 18; BPIFA1, BPI fold containing family A member 1; SLPI, secretory leukocyte peptidase inhibitor; BPIFB1, BPI fold containing family B member 1; STATH, statherin; LTF, lactotransferrin.
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