Figure 2
Fully extended forms of IgE-Fc. (a) Overall structure of IgE-Fc in the aεFab/IgE-Fc complex24. IgE-Fc chains A and B are coloured blue and green, respectively. (b) Overall structure of IgE-Fc in the 8D6 Fab/IgE-Fc complex. IgE-Fc chains A and B are coloured yellow and pink, respectively. (c) “Top” view of the Cε3 domains in the aεFab/IgE-Fc complex24. (d) “Top” view of the Cε3 domains in the 8D6 Fab/IgE-Fc complex. (e) Fcε3-4 domains in the aεFab/IgE-Fc complex. (f) Fcε3-4 domains in the 8D6 Fab/IgE-Fc complex. The arrows indicate that the domains adopt a more closed conformation. (g) (Cε2)2 domain pair position in the aεFab/IgE-Fc complex24. The curved arrow indicates that the (Cε2)2 domain pair rotates to generate the position observed in the 8D6 Fab/IgE-Fc complex, shown in h. (h) (Cε2)2 domain pair position in the 8D6 Fab/IgE-Fc complex.
