Figure 1

Synthesis schematic of gold-silica-coated MIONs. Iron oxide cores (JHU MIONs, 1) were coated with silica using tetraethylorthosilicate to form Si-MIONs (2). The Si-MIONs were amine-terminated using 3-aminopropyltrimethoxysilane and seeded by a colloidal gold solution containing 1–2 nm gold seeds. Finally, a gold shell was grown on the surface by the reduction of chloroauric acid to form AuSi-MIONs (3).