Figure 6 | Scientific Reports

Figure 6

From: In vivo neutralization of the protagonist role of macrophages during the chronic inflammatory stage of Huntington’s disease

Figure 6

Clodronate liposome normalisation of cytokine levels in late-stage R6/2 mice. (a) Clodronate liposome treatment reduced IL1β, IL2 and IL6 levels in late-stage R6/2 mice post IV treatment (n = 8–12/group). Mean concentration of IL10, IL1β, IL2, IL6 and TNFα ± SEM following clodronate liposome IV injection, at the day of greatest splenic M0 depletion and one day later as assessed by MSD. (b) Clodronate liposome treatment normalised TNFα, IL2 and IL6 levels in late-stage R6/2 mice post IP treatment (n = 9–12/group). Mean concentration of TNFα, IL1β, IL2, IL6 and IL10 ± SEM following clodronate liposome IP injection, at day of highest splenic M0 depletion and one day later as assessed by MSD. All comparisons to R6/2 levels at day 0, ANOVA with Bonferroni correction. *p < 0.05, #p = 0.06. WT = wild type, IV = intravenous, IP = intraperitoneal, M0 = splenic macrophages.

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