Table 2 LogP values of 99mTc-RYM1 and RP805. The data represent the mean ± SD of 2 independent experiments, each performed with triplicate determinations.

From: Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation

LogP

Octanol/Tris*

Octanol/water

RP805

−3.2 ± 0.1

−2.8 ± 0.0

99mTc-RYM1

−4.4 ± 0.1

−4.0 ± 0.1

  1. *pH 7.4.
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