Figure 2 | Scientific Reports

Figure 2

From: oxLDL inhibits differentiation and functional activity of osteoclasts via scavenger receptor-A mediated autophagy and cathepsin K secretion

Figure 2

oxLDL inhibits the cytoskeletal rearrangement of osteoclasts. Monocytes plated on glass coverslips were grown in the presence of M-CSF and RANKL for a total of 15 days and cells were analyzed by confocal microscopy. (A) Mature osteoclasts were stained FITC-phalloidin (green) and with antibody against CatK (red) and nuclei (DAPI, blue). White arrows indicate disrupted cytoskeleton. (B) Mature osteoclasts were stained FITC-phalloidin (green) and with antibody against vinculin (red) and nuclei (DAPI, blue). White arrows indicate disrupted actin binding. Magnification x40, scale bar 50 µm. n ≥ 3.

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