Table 1 Gene function and biological process associated with C.

From: A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion

GO category

Gene name

p-valuea

Up-regulated transcripts

Drug transport

CDR1, CDR11, QDR3, MDR1, TPO3, MTE4, SGE11, C1_10710C_A, CR_09830W_A

1.30e-04

Trehalose metabolism in response to stress

HSP21, NTH1, HSP104, TPS2

2.10e-02

Glyoxylate metabolic process

GOR1, ICL1, MLS1, C4_05390W_A

5.17e-02

Carbohydrate metabolic process

GAL1, GAL10, TPS2, ICL1, PFK26, MLS1, PFK27,

HSP21, GPD1, PYC2, XKS1, NTH1, GSY1, HSP104

6.25e-02

Oxidation-reduction process

GOR1, AOX2, ERO1, FMP52, MRF1, C2_07270W_A,

IFM3, UCF1, GPD1, DAO2, SCS7, C4_05390W_A, OYE32, GPX1, OYE23, MIX17, NPD1, ALK2, GSY1, IFE2, CDG1

7.63e-02

Down-regulated transcripts

Lipid biosynthetic process

CWH8, FEN1, LCB2, DGK1, AYR1, ERG6, LAC1, IDI1, PEL1, CYB5, EPT1, COQ1, ERG25, CHO2, NDT80

1.34e-03

Regulation of protein serine/threonine kinase activity

RHO2, SOL1, WSC1, PBS2, CLN3, CIP1, CLG1

7.82e-03

Filamentous growth

CHS7, RAC1, CAT1, VRG4, SSU81, UTP6, GIN4, NDT80, ESC4, RHO2, RAS1, ASH1, MNT2, CCC1, WSC1, LAC1, MNN9, PBS2, ISW2, CLN3, CHT2, TOP1, CUP9, YEL1, RSR1, SMC5, PGA1

5.07e-02

Fungal-type cell wall organization or biogenesis

XOG1, CHS7, RAC1, SSU81, FEN1, SIM1, SPF1,

RHO2, MNT2, WSC1, CHS4, MNN9, PBS2, PGA1

5.99e-02

  1. Albicans response to Niclosamide. Gene ontology analysis was performed using the Candida Genome Database GO Term Finder. aThe p-value was calculated using hypergeometric distribution, as described on the GO Term Finder website.
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