Table 1 Effect of CG200745 on real function.

From: Histone deacetylase inhibitor, CG200745 attenuates renal fibrosis in obstructive kidney disease

 

Control

UUO

UUO + CG

BW (g)

23.9 ± 0.12

23.9 ± 0.64

24.5 ± 0.53

KW/BW (g/kg)

5.7 ± 0.18

6.6 ± 0.23*

6.0 ± 0.16

UO (ml/day)

2.2 ± 0.15

3.4 ± 0.28*

4.6 ± 0.89

BUN (mg/dl)

28.2 ± 0.40

26.6 ± 1.71

30.1 ± 2.08

PCr (mg/dl)

0.09 ± 0.01

0.152 ± 0.03

0.103 ± 0.02

Plasma NGAL (ng/ml)

461.0 ± 27.8

2155.7 ± 387.7*

701.0 ± 153.0#

  1. Abbreviations: UUO, unilateral ureteral obstruction; CG, CG200745; BW, body weight; KW, kidney weight; UO, urine output; BUN, blood urea nitrogen; PCr, plasma creatinine; NGAL, neutrophil gelatinase-associated lipocalin.
  2. *p < 0.05 compared with control. #p < 0.05 compared with UUO. Values are expressed as the mean ± SEM.
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