Figure 5 | Scientific Reports

Figure 5

From: Invasive meningococcal disease in Shanghai, China from 1950 to 2016: implications for serogroup B vaccine implementation

Figure 5

Minimum-spanning tree analysis of multilocus sequence types of invasive and carriage N. meningitidis before and after introduction of meningococcal vaccines in China. Isolates were obtained during the pre-MPV-A (1965–1980), post-MPV-A (1981–2008), and post-MPV-A + C (2009–2016) periods. Sequence types (STs) are displayed as circles. The size of each circle indicates the number of isolates with this particular type. Serogroup is distinguished by different colours. The shaded halo surrounding the STs encompasses related sequence types that belong to the same clonal complex. Heavy solid lines represent single-locus variants, and light solid lines represent double-locus variants. Sequences types sharing no less than 4 loci, but not assigned to any clonal complexes in the PubMLST database were assigned to ST-clusters. NG, nongroupable.

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