Table 2 Summary of the fetal offspring obtained through Exp-1 and -2.

From: i-GONAD (improved genome-editing via oviductal nucleic acids delivery), a convenient in vivo tool to produce genome-edited rats

Experiment

No. pregnant rats/no. rats treated

No. fetuses obtained

No. fetuses carrying de-pigmented eyes (%)

Fetuses with modified alleles

No. homozygous or compound heterozygous bi-allelic mutation (%)

No. heterozygous bi-allelic mutation (%)

No. mosaic mutation (%)

Exp-1 (mating between female BN and male SD)

3/5

13

8 (62)

2 (25)

6 (75)

0 (0)

Exp-2 (mating between female SD and male BN)

3/3

16

9 (56)

1 (11)

5 (56)

3 (33)