Figure 7
From: Metabolic network-based predictions of toxicant-induced metabolite changes in the laboratory rat
Heat map of TIMBR production scores compared to metabolic profiling data obtained 10 h after APAP treatment under fasting conditions. iRno model predictions calculated under two integration conditions were compared against log2 fold changes of metabolites that significantly (FDR < 0.10) changed in the global metabolic profiling data (Data). In one condition, only gene expression changes were used (No MFA), whereas in the other both gene expression changes and MFA data were used as constraints (MFA). The numbers in the heat map show the log2 fold changes of the metabolic profiling data (left column) and TIMBR production scores under the no MFA (center column) and MFA (right column) conditions. The color scheme on the far right shows the degree of change in the level of a plasma metabolite, from highly increased (dark red) to highly decreased (dark blue).
