Figure 1

Mitochondrial m.3243A > G associations with digit symbol substitution test score (linear regression p = 0.04), fasting insulin (linear regression p = 0.04), pulse wave velocity (PWV, linear regression p = 0.008), and grip strength (linear regression p = 0.018) compared across tertiles of m.3243A > G heteroplasmy. A total of 263 participants were included in each tertile of m.3243A > G heteroplasmy. Bars indicate tertiles that were combined for analyses comparing phenotypes among low, middle, and high heteroplasmy levels. Asterisks (*) indicate statistically significant differences among individual and/or combined tertiles with p-values reported. Values and analyses adjusted for age, sex, race, and clinic site.