Table 2 Phenotype values among tertiles of m.3243A > G heteroplasmy, mean and standard error (SE).

From: Mitochondrial DNA m.3243A > G heteroplasmy affects multiple aging phenotypes and risk of mortality

m.3243A > G heteroplasmy

0–4%

4–6%

6–19%

Linear p-value

Mean (SE)

Mean (SE)

Mean (SE)

Digit Symbol Substitution Test Score

35.3 (0.73)

33.1 (0.73)

33.1 (0.73)

0.04

Fasting insulin (uIU/mL)

7.65 (0.55)

8.30 (0.55)

9.80 (0.55)

0.04

Pulse wave velociy (cm/sec)

890 (27.8)

928 (28.3)

976 (28.6)

0.008

Grip Strength (kg)

31.8 (0.43)

30.9 (0.43)

30.4 (0.43)

0.02

Modified Mini-Mental State Examination Score

91.5 (0.3)

90.8 (0.3)

90.9 (0.3)

0.49

400 m walk speed (m/s)

1.24 (0.013)

1.25 (0.013)

1.23 (0.013)

0.94

Systolic blood pressure (mm Mercury)

137.2 (1.3)

136 (1.3)

136.2 (1.3)

0.30

Resting heart rate (beats/min)

68.2 (0.67)

67.5 (0.67)

67.3 (0.66)

0.13

Fasting glucose (uIU/mL)

101.7 (1.89)

105.5 (1.9)

104.7 (1.9)

0.90

  1. A total of 263 participants were included in each tertile of m.3243A > G heteroplasmy. All values were adjusted for age, sex, race, and clinic site.