Figure 1 | Scientific Reports

Figure 1

From: Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1β production by DCs

Figure 1

Chitin amplifies the development of OVA-induced airway inflammation. (a) Scheme of induction of allergic airway inflammation by OVA in mice sensitized intranasally with or without OVA ± chitin. BALB/c-wild-type mice were repeatedly intranasally sensitized with OVA, chitin, OVA + chitin or saline alone, and then challenged intranasally with OVA. Twenty-four h after the last OVA challenge, samples were collected for the following experiments. (b) The number of cells in BALFs. (c) Lung sections (hematoxylin and eosin staining, x 200). (d) Serum levels of OVA-specific IgE, IgG1 and IgG2a. (e) Cytokine levels in culture supernatants of spleen cells after in vitro restimulation with OVA. Data are pooled from 2 independent experiments and shown as the mean ± SE (b, d and e). 1-way ANOVA, *P < 0.05.

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