Figure 3 | Scientific Reports

Figure 3

From: Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1β production by DCs

Figure 3

Chitin amplifies development of OVA-induced airway inflammation dependent on IL-4/13 and STAT6, but independently of IL-17. (a) The number of eosinophils in the BALFs from C57BL/6-wild-type and -Il17a−/− mice intranasally sensitized with or without OVA ± different sizes of chitin particles and challenged with OVA, as shown in Fig. 1a. (b) The number of eosinophils and levels of EPO activities in the BALFs from BALB/c-wild-type, -Stat6−/− and Il4−/−Il13−/− mice sensitized with or without OVA ± chitin (<100 µm) and challenged with OVA, as shown in Fig. 1a. (c) Levels of OVA-specific and total IgE in sera from mice in B. (d) Levels of IL-4 and IL-13 in culture supernatants of spleen cells from mice in b after in vitro restimulation with OVA. Data are pooled from 2 independent experiments and shown as the mean ± SE. 1-way or 2-way ANOVA, *P < 0.05.

Back to article page