Figure 4 | Scientific Reports

Figure 4

From: Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1β production by DCs

Figure 4

Chitin amplifies development of OVA-induced airway inflammation dependent on IL-33, but not IL-25 or TSLP. BALB/c-wild-type, -Il33−/−, -Il25−/− and Crlf2−/− mice were intranasally sensitized with or without OVA ± chitin and then challenged intranasally with OVA, as shown in Fig. 1a. (a) The number of eosinophils in the BALFs. (b) Levels of OVA-specific IgE in sera. (c) Levels of IL-13 in culture supernatants of spleen cells after in vitro restimulation with OVA. The data are pooled from at least 3 independent experiments and shown as the mean ± SE. 1-way or 2-way ANOVA, *P < 0.05.

Back to article page