Figure 5 | Scientific Reports

Figure 5

From: Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1β production by DCs

Figure 5

Chitin abolishes tolerogenic immune responses at airway. (a) Scheme of inhalation tolerance during OVA-induced airway inflammation. BALB/c-wild-type mice were intranasally exposed to OVA, OVA + chitin or saline prior to intraperitoneal sensitization with OVA/alum. After the sensitization, mice were challenged intranasally with OVA or saline. (b) The number of eosinophils in the BALFs. (c) Levels of OVA-specific IgE in sera. (d) Levels of IL-4 in culture supernatants of spleen cells after in vitro restimulation with OVA. Data are pooled from 4 independent experiments and shown as the mean ± SE. Mann–Whitney U test, *P < 0.05.

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