Table 3 The top 4 most significantly different pathways between the three most common cerebellar tumors.

From: Tissue metabolite profiles for the characterisation of paediatric cerebellar tumours

Metabolic pathway

Total number of compounds

Hits

P value

Impact

Pairwise P values

Med vs Epen

Med vs PA

Epen vs PA

Glycerophospholipid metabolism

39

4

5.5 × 10−20

0.20

1.0 × 10−8

8.6 × 10−11

N.S.

Taurine and hypotaurine metabolism

20

4

3.6 × 10−15

0.44

1.9 × 10−3

9.1 × 10−9

4.9 × 10−5

Alanine, aspartate and glutamate metabolism

24

7

5.2 × 10−15

0.81

6.0 × 10−3

3.2 × 10−11

2.0 × 10−4

Arginine and proline metabolism

77

5

1.3 × 10−14

0.087

5.9 × 10−3

4.8 × 10−11

2.5 × 10−4

  1. Glycerophospholipid metabolism is enriched in medulloblastoma compared to the other two tumor types. The alanine, aspartate and glutamate metabolism pathway has the highest topological metric, and it is likely that this pathway is strongly associated with tumor type.