Figure 2

MRI-based lesion symptom mapping. Shown are the brain regions that overlap with an impaired fat perception in the category f3. For f1, we also found significant differences in fat ratings between patients and controls. VSLM, however, revealed no significant effects for f1 (see Fig. 1 for corresponding sugar and fat ratings). The ‘z’ below each brain slice indicates the corresponding z-coordinate of that slice in MNI space. ‘L’ indicates the left and ‘R’ the right hemisphere. We found that an impaired fat perception in f3 overlapped with the anterior insular cortex together with the frontal operculum. Both regions are together assumed to underpin gustatory processing. We also found the mid-dorsal insula together with the primary and secondary somatosensory cortex - regions that are assumed to integrate sensory-oral inputs. At the bottom of the figure we show a render brain with a coronal cut through the primary somatosensory cortex. TPJ indicates the temporoparietal junction, S1 the primary somatosensory cortex. The effect in f3 appears to overlap with the representations of the face including the oral cavity as well as the tongue.