Figure 8 | Scientific Reports

Figure 8

From: Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids

Figure 8

Immunohistochemical evidence of L2A5 mAb staining in colorectal cases and comparison with established anti-STn mAbs. (A) Immunohistochemical staining of colorectal cancer tissues. Paraffin embedded tissues were stained with L2A5 and B72.3 mAbs. Images show that L2A5 mAb reactivity shows slightly higher extension and intensity staining compared to B72.3 mAb. (B) Immunohistochemical staining of normal colorectal tissues. Paraffin embedded tissues were stained with L2A5 and B72.3 mAbs. Representative images show L2A5 unspecific staining towards enterocytes (arrow) and B72.3 unspecific staining mainly observed in goblet cells.

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