Figure 1

Derivation of NLR and correlation with clinicopathology. (a) An optimal cut-off for high NLR (>2.5) in predicting overall survival was determined using receiver operating curve analyses. (b) Patients with distant metastasis at diagnosis, higher tumor grade, larger tumor size, as well as tumor depth were associated with higher NLR. (c) Progression of localized disease at diagnosis to metastatic relapse within the same patients was associated with an increase in NLR (p = 0.0003, Wilcoxon signed-rank test). (d) In histotype-specific analysis, liposarcomas (LPS) with dedifferentiated components or retroperitoneal primary sites were significantly associated with higher NLR. Undifferentiated pleomorphic sarcomas (UPS) and synovial sarcomas (SS) of the extremities had lower NLR. No difference was observed for uterine leiomyosarcomas (LMS) or skin angiosarcomas (AS) compared to other primary sites. *p < 0.05, **p < 0.001, ***p < 0.0001 by Mann-Whitney U test. ns, non-significant; sup, superficial.