Figure 3

P7 EEG power analysis. (A) ANA12 + PB reduced electrographic seziure burden in a dose-dependent manner. (B) Power spectrum of PB alone and 5 mg/kg of ANA12 + PB. (C) No groups had significantly reduced EEG power in the 2^nd h. All comparisions done via two-way ANOVA. (D) All doses of ANA12 + PB significantly increased the EEG power reduction ratio compared to PB alone. (Between group comparisons to PB alone were done using independent t-tests; *P < 0.05, **P < 0.01, ***P < 0.001.) (E) Mean EEG power over the course of the 2 h recordings. (E1) 15 minutes post-PB injection showed ANA12 + PB significantly reduced EEG power at all doses. (Between group comparisons to PB alone were done with one-way ANOVAs; ANA12, 0.5 mg/kg: *P < 0.05; ANA12, 2.5 mg/kg: ^@P < 0.01; ANA12 5 mg/kg: ^#P < 0.05). (E2) Line graphs show percent seizure suppression and associated EEG powers for each treatment group at 15 minutes post-PB injection. All doses of ANA12 + PB had significant associations between seizure suppression and EEG power reduction at 15 min post-PB injection and PB alone did not. Percent seizure suppression vs. EEG power was done using paired t-tests; ^γP < 0.05, ^γγP < 0.01, ^γγγP < 0.001.