Table 2 EEG Seizure Statistics (*P < 0.05, **P < 0.01, ***P < 0.001).

1st hr seizure burden

1152.5 ± 71.9

1135.0 ± 83.5

1207.5 ± 71.9

1044.4 ± 90.9

2nd hr seizure burden

1109.6 ± 94.4

858.5 ± 74.3

711.7 ± 79.7

354.4 ± 61.3

2 way ANOVA F_{3, 174} = 6.145; P = 0.0005*** post-hoc 1st vs 2nd hr

p > 0.9999

p = 0.62

p = 0.0003***

p ≤ 0.0001***

post-hoc vs 5 mg/kg

p < 0.0001***

p = 0.0006***

p = 0.041*

N/A

1st hr ictal events

49.3 ± 2.2

43.3 ± 3.0

46.2 ± 2.1

36.7 ± 3.1

2nd hr ictal events

36.42 ± 2.8

30.0 ± 3.0

27.0 ± 2.7

15.9 ± 2.3

2 way ANOVA: F_3,174 = 1.169; P = 0.3229 post-hoc 1st hr vs 2nd hr

p = 0.0143*

p = 0.0275*

p ≤ 0.0001***

p ≤ 0.0001***

1st hr ictal duration

23.54 ± 1.27

27.31 ± 1.90

26.57 ± 1.51

28.35 ± 1.16

2nd hr ictal duration

31.41 ± 2.16

31.45 ± 2.31

26.03 ± 1.86

21.84 ± 2.81

2 way ANOVA: F_3,174 = 5.161; P = 0.0019** post-hoc 1st hr vs 2nd hr

p = 0.0964

p > 0.9999

p > 0.9999

p = 0.4857

B) P10 seizure stats

+PB

0.5 mg/kg ANA12 + PB

2.5 mg/kg ANA12 + PB

5 mg/kg ANA12 + PB

1st hr seizure burden

711.8 ± 87.4

899.1 ± 86.4

758.3 ± 88.6

606.4 ± 62.7

2nd hr seizure burden

314.6 ± 53.1

198.2 ± 50.9

140.8 ± 43.2

54.6 ± 15.3

2 way ANOVA F_3,82 = 1.903; P = 0.1356 post-hoc 1st vs 2nd hr

p = 0.0018**

p ≤ 0.0001***

p ≤ 0.0001***

p ≤ 0.0001***

1st hr ictal events

42.3 ± 5.1

46.7 ± 4.6

42.9 ± 4.4

33.7 ± 3.7

2nd hr ictal events

19.3 ± 2.7

13 ± 2.8

10.5 ± 3.3

4.0 ± 1.0

2 way ANOVA: F_3,174 = 1.169; P = 0.3229 post-hoc 1st hr vs 2nd hr

p = 0.0011**

p ≤ 0.0001***

p ≤ 0.0001***

p ≤ 0.0001***

1st hr ictal duration

16.85 ± 0.75

21.69 ± 3.11

18.02 ± 1.79

18.20 ± 0.65

2nd hr ictal duration

15.91 ± 1.88

12.68 ± 2.58

13.53 ± 1.14

9.93 ± 1.99

2 way ANOVA: F_3,174 = 5.161 P = 0.0019** post-hoc 1st hr vs 2nd hr

p > 0.9999

p = 0.0375*

p > 0.9999

p = 0.0867