Table 1 Combination studies between ADI-PEG20 or rhArg1peg5000 and chemotherapy.

From: Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

 

ADI-PEG20

rhArg1peg5000

IC50

IC90

IC50

IC90

5-FU

HCT116

1.42

1.25

1.73

1.63

SW480

—

—

1.76

1.08

RKO

1.18

1.1

1.05

1.09

HT29

0.89

0.80

1.41

1.25

Oxaliplatin

HCT116

1.24

1.46

1.92

1.60

SW480

—

—

1.54

1.22

RKO

0.61

0.80

1.89

1.59

HT29

0.61

0.80

1.33

1.09

  1. CI values are reported for both IC50 and IC90 combinations in the indicated cell lines. CI < 1 indicates synergism, CI = 1 indicates addictive effect, CI > 1 indicates antagonism. Cells were counted after 6 days of treatment and data obtained from diagonal constant ratio combinations were analyzed for synergism, additivity or antagonism using the CompuSyn Software (CompuSyn Inc.) according to the Chou and Talalay method.  Bold highlights significant synergisms (P < 0.05).
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