Figure 3 | Scientific Reports

Figure 3

From: Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor

Figure 3

AGS cells treated with IC50 concentrations of KPT-330 for 24 hours was analysed for cell cycle profiles and apoptosis (a) Cell cycle analysis (b) Annexin-FITC apoptosis assay. (c) Immunoblots of apoptotic protein expressions in AGS cells treated with varying doses of KPT-330 for 24 hours. The values reported under each blot indicates the percentage expression of cleaved caspase 3 & 9 relative to controls taken as 1 after normalization by GAPDH (Image J quantification). The results shown are representative of two independent experiments.*p-value of less than 0.05 was considered statistically significant.

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