Table 2 Different pharmacokinetic parameters calculated from plasma level-time curve obtained after oral administration of DTX suspension and NCs to rabbits.

From: Polymeric nanocapsules embedded with ultra-small silver nanoclusters for synergistic pharmacology and improved oral delivery of Docetaxel

Pk Parameter

Unit

DTX

DTX-Ag-NCPs

Tmax

h

5

3

Cmax

ng/ml

41.78

297.39

t1/2

h

18.039

123.46

AUC0–24

ng/ml*h

440.70

3921.46

AUMC0-inf_obs

ng/ml*h^2

19100.51

4664644.30

MRT0-inf_obs

h

26.16

174.08

Cl/F_obs

(mg)/(ng/ml)/h

0.014

0.00037

F

 

1

8.89

  1. Abbreviations: DTX-Ag-NCPs = Docetaxel loaded and NCs conjugated thilated chitosan hybrid nanoclusters, DTX = Docetaxel solution (control), Tmax = time to reach maximum concentration, Cmax = maximum concentration in blood, t1/2 = half life in blood, AUC0–24 = area under the curve from time 0 to 24 h, AUMC0-inf_obs = , MRT0-inf_obs = mean residence time observed, C1/Fobs = , F = fraction.
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