Table 2 Overrepresented signaling pathways of DOCK8 interacting proteins in PBL of healthy controls.

From: Interaction of septin 7 and DOCK8 in equine lymphocytes reveals novel insights into signaling pathways associated with autoimmunity

Signaling pathway

p-value

No. of proteins observed

List of observed proteins (gene symbols)

ARP2 Actin Related Protein 2 Homolog (Yeast)

3,85E-08

6

ACTR2, GSN, VCL, ACTB, ARPC4, ACTR3

Small GTP-binding Protein RAC

3,13E-04

8

ACTR2, FERMT3, RSU1, DOCK8, CORO1C, IQGAP1, C1QA, PARVB

Myosin light chain kinase

6,35E-04

4

ACTN1, MYO18A, MYH10, MYL9

  1. List of the top 3 significantly (p-value) enriched signaling pathways containing DOCK8-interacting proteins enriched in healthy PBL (≥2 peptide counts; enrichment factor ≥4) analyzed by Genomatix (version 3.7).
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