Figure 6
Assessment of the association between protein expression changes and Alzheimer’s disease status. Protein expression and associations with AD status for AQP4, DTNA, MLC1, and FXYD1. Expression changes measured in HIP (ndementia = 10–15, nnon-dementia = 10–12) and FCX (ndementia = 13–20, nnon-dementia = 15–17). For each gene, plots describe associations with AD status in each brain region (A–D). In HIP, elevated expression of DTNA (p = 0.031) and MLC1 (p = 0.025) significantly predict dementia status. Statistical associations calculated with logistic regression. The bars in (A–D) represent the mean ± the standard error of the mean (S.E.M.). Complete statistical information found in Table 4. Representative blots have been cropped for clarity. Dotted lines represent the boundary between cropped images. All blots were processed in parallel across subjects. Full length representative blots can be found in Supplementary Fig. 2.
