Figure 5 | Scientific Reports

Figure 5

From: Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis

Figure 5

Erythropoiesis is delayed in Nan spleen. (a) Total, CD45 positive and CD45 negative cell counts in WT, Nan, and WT-PHB spleen (n = 3, 10, and 4, respectively) and bone marrow (n = 4/group). (b) Quantitation of the different spleen populations demonstrates an accumulation of pro-, baso and- polychromatophilic erythroblasts in Nan spleen (top panel) and baso- and- polychromatophilic erythroblasts in Nan bone marrow (bottom). As a result, production of orthochromatophilic erythroblasts markedly lags that of WT-PHB. n = 4/group. *P < 0.05; **p < 0.01; ***p < 0.001.

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