Figure 3 | Scientific Reports

Figure 3

From: Plasma proteomics reveals gestational age-specific responses to mechanical ventilation and identifies the mechanistic pathways that initiate preterm lung injury

Figure 3

Network mapping of differential protein expression was GA-specific. Log2 fold changes and the GA-specific IPA-derived network pathways associated with differentially-expressed proteins in (A) extremely preterm, (B) preterm and (C) term ventilated lambs (P < 0.05, paired t-test pre-ventilatoin vs. 60 minute post-ventilation). Red and green nodes/text represent increased and decreased protein expressionat 60 minutes ventilation, relative to matched pre-ventilation samples. Proteins shown by white nodes were not identified in plasma samples. Solid lines indicate direct interactions or relationships, while dashed lines indicate indirect effects mediated by additional proteins. Proteins known to be influenced by antenatal betamethasone are shown in italics.

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