Table 1 Mean pharmacokinetic parameters for valsartan capsules after a single oral administration in beagles of 80 mg valsartan per beagle (n = 12).

From: Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability

Parameters

Fasted state

Fed state

AUC0–12h (mg/L · h)

6.58 ± 2.45*

1.22 ± 1.60

Tmax (h)

1.75 ± 0.99

0.98 ± 0.63

Cmax (mg/L)

2.00 ± 0.77*

0.42 ± 0.37

t1/2 (h)

1.92 ± 0.97

3.48 ± 1.77

CL/F (L/h/kg)

1.10 ± 0.37*

8.34 ± 3.68

  1. Data were reported as mean ± SD. Comparison between groups was done by t-test. *p < 0.05, compared with fed state.
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