Table 2 Pharmacokinetic parameters of valsartan capsules in beagles catalogued into four types in fed state of 80 mg valsartan per beagle.

From: Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability

Parameters

Food taking patterns-“4P Modes”

Persisting

Pulsing

Postponing

Pushing

AUC0–12h (mg/L · h)

0.60 ± 0.14

0.81 ± 0.26

2.98 ± 2.89*

0.53 ± 0.04

Tmax (h)

1.08 ± 0.88

1.13 ± 0.75

0.67 ± 0.29

1.00 ± 0.71

Cmax (mg/L)

0.19 ± 0.03

0.32 ± 0.18

0.96 ± 0.32*

0.17 ± 0.04

  1. Data were reported as mean ± SD. Comparison between groups was done by t-test. *p < 0.05, “Postponing” group was compared as the reference with other three groups.
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