Figure 1 | Scientific Reports

Figure 1

From: Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer

Figure 1

Different biological behaviours in two pairs of ovarian cancer cell lines. In flow cytometry (A), a–c were SKOV3 cell lines and d–f are SKOV3-DDP cell lines treated with 2, 5, or 8 mg/l of cisplatin. Q1, Q2, Q3, Q4 represent dead cells, late apoptotic cells, survival cells, and early apoptotic cells, respectively. At different concentrations of 2, 5, or 8 mg/l, SKOV3 and SKOV3-DDP cells have significant differences in cisplatin resistance (p < 0.05) (B). For HO-8910PM and HO-8910 cell lines, pictures were taken of the cells at 0 h, then incubated overnight, and photographed again. Cell migration distance in the HO-8910 cell line was less than that in the HO-8910PM cell line (p < 0.01) (C). Cells were incubated on migration wells for 48 h, the number of cells that migrated to the lower side of the filter were counted (D). The results are shown as the mean ± SD (p < 0.01 compared to the HO-8910 cell line).

Back to article page