Figure 3 | Scientific Reports

Figure 3

From: Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer

Figure 3

Analysis of protein/DNA arrays. Using the expression in SKOV3 and HO-8910 cells as a benchmark, differential expression of transcription factors was observed in the SKOV3-DDP/SKOV3 or HO-8910PM/HO-8910, increased or decreased by two-fold, respectively. Forty-three transcription factors were up-regulated (green) and thirty-one down-regulated (red) in SKOV3 and SKOV3-DDP cells (A). Thirteen transcription factors were up-regulated (green) and eighteen down-regulated (red) in HO-8910PM and HO-8910PM cells (B). In conclusion, four up-regulated (green), and nine down-regulated (red) transcription factors were associated with ovarian cancer cisplatin-resistance and metastasis (C). The concrete activities were shown (D,E).

Back to article page