Table 2 Clinical Characteristics.

From: Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: a Human Study

 

Normal control (n = 19)

Takotsubo syndrome (n = 26)

Dilated cardiomyopathy (n = 26)

P-value

Left ventriculography data

  LVEDV (mL/m2)*

72.8 ± 22.0

78.3 ± 17.1

122.0 ± 33.1

<0.001

  LVESV (mL/m2)*

26.1 ± 10.3

41.3 ± 16.6

81.9 ± 27.0

<0.001

  LVEF (%)

64.0 ± 9.4

47.8 ± 14.0

33.2 ± 8.9

<0.001

Laboratory data on admission

  Uric acid (mg/dL)

6.4 ± 1.9

4.9 ± 1.3

7.0 ± 2.4

0.002

  eGFR (mL/min/1.73 m2)†

73.1 ± 24.7

74.3 ± 20.9

73.7 ± 25.4

0.72

  Corrected serum calcium (mg/dL)

9.4 ± 0.3

8.9 ± 0.4

9.2 ± 0.4

0.006

  BNP (pg/mL)

66.2 ± 8.4

489.7 ± 406.6

678.5 ± 932.4

<0.001

  PRA (ng/mL/hr)

2.5 ± 2.8

3.2 ± 6.2

4.3 ± 6.8

0.29

  PAC (pg/mL)

154.5 ± 109.5

121.5 ± 127.6

145.1 ± 156.8

0.24

  Plasma adrenaline (pg/mL)‡§

n/a

78.0 (38.0–268.7)

n/a

 

  Plasma noradrenaline (pg/mL)‡¶

n/a

671.0 (265.5–1169.5)

n/a

 
  1. Values are mean ± standard deviation or median (25th–75th percentile) as appropriate. *Left ventricular end-diastolic volume (LVEDV) index (LVEDVI = LVEDV/body surface area (BSA)) and left ventricular end-systolic volume (LVESV) index (LVESVI = LVESV/BSA) were calculated by means of the area–length method. †Estimated glomerular filtration rate (eGFR) was calculated according to the published equation for Japanese subjects: 194 × serum creatinine−1.094 × age−0.287 × (0.739 for women). ‡Plasma adrenaline and noradrenaline were measured within 1.1 ± 1.0 days after admission in 12 patients of the TTS group. §The normal range of plasma adrenaline is 0–100 pg/mL. The normal range of plasma noradrenaline is 100–450 pg/mL. LVEF: left ventricular ejection fraction, BNP: brain natriuretic peptide, PRA: plasma renin activity, PAC: plasma aldosterone concentration.
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