Figure 1 | Scientific Reports

Figure 1

From: HDAC4 degradation by combined TRAIL and valproic acid treatment induces apoptotic cell death of TRAIL-resistant head and neck cancer cells

Figure 1

Combined TRAIL and VPA treatment induced cytotoxicity in head and neck cancer cell lines. (A) FaDu, HN3 and SNU899 were treated with TRAIL (0.5, 1 µg/ml) and/or VPA (2.5, 5, 10, 20 mM) for 24 h. MTT assay was used to measure cell viabilities. (*p < 0.05; **p < 0.01; ***p < 0.001) (B) HN3 cells were treated with TRAIL (0.5 µg/ml) and VPA (5 mM), and then the cells were stained with annexin V-FITC and propidium iodide and analyzed via flow cytometry. (C) Cell death by combination TRAIL and VPA was determined using a light microscope.

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