Figure 3 | Scientific Reports

Figure 3

From: Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer’s disease mice and correlates with memory deficits in human subjects

Figure 3

Protein levels of calpain-2 are increased in synaptosomes of APP/PS1 mice early in the disease pathogenesis. While immunoreactive levels of calpain-2 were unaltered in synaptosomes of 1 month old APP/PS1 mice (A), calpain-2 levels were significantly increased at 3 months (B) and 9–10 months (C) of age when compared to age matched WT controls. Values are mean ± SD (n = 7–10 mice) and ** denotes values significantly different from corresponding controls (p < 0.01; Mann Whitney test). In (A), re-probe for tubulin was performed without stripping and in (B), the blot was cut along the dotted line. Full representative blots are also shown in Supplementary data (Supplementary Figs 3–5).

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