Figure 5 | Scientific Reports

Figure 5

From: Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer’s disease mice and correlates with memory deficits in human subjects

Figure 5

Global protein levels of calpain-2 are unaltered in PNS of APP/PS1 mice at both pre-symptomatic and early symptomatic ages. Global protein levels of calpain-2 as assessed by immunoreactivity in cortical PNS fractions of APP/PS1 mice were similar to aged matched WT controls at ages of 1 month (A), 3 months (B) and 10 months (C). Values are mean ± SD (n = 7 mice) and p values are calculated using Mann Whitney test. See full representative blots in Supplementary data (Supplementary Figs 9–11).

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