Figure 6
Conservation analysis of the GatD/MurT surface. (a) Inner and (b) outer surface of the GatD/MurT crystal structure colored by a color gradient indicating conservation, as shown on the top of the figure. Conservation scores were calculated with ConSurf34 and mapped onto the protein surface as described in the methods section. Dark blue signifies a high conservation score. Most of the concave surface of GatD/MurT is highly conserved, whereas the remaining surface displays high variability. The AMPPNP ligand is shown with white spheres, and the location of the catalytic triad and the conserved DNAAD sequence that has been implicated in muropeptide binding are indicated as well.
