Figure 1
From: Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
Ferric ion-containing transferrin induced dielectric heat in the 13.56 MHz radiofrequency wave to boost temperature elevation in vitro. (a) Either apotransferrin or transferrin solutions of the indicated amount were irradiated by the same amount of 13.56 MHz radiofrequency wave under the same condition, and temperature changes were indicated. The temperature was recorded by FLIR thermal camera before and after 13.56 MHz radiofrequency hyperthermia and temperature change (ΔT) was calculated. The transferrin solution containing ferric ion showed significant temperature elevation compared to apotransferrin solution without ferric ion. (b) Exposure of human lung cancer NCI-H460 cells to transferrin boosted temperature elevation in a dose dependent manner while this effect was not observed in normal primary cells. The values represent the mean ± standard deviation (n = 6). A paired Student’s t-test was used for the statistical analysis; *p < 0.05.
